Visible-Light Promoted Regioselective Oxygenation of Quinoxalin-2(1H)-ones Using O₂ as an Oxidant

Sudip Sau and Prasenjit Mal*

*School of Chemical Sciences, National Institute of Science Education and Research (NISER), Via Jatni, District Khurda, Odisha 752050, India, Email: pmalniser.ac.in

S. Sau, P. Mal, J. Org. Chem., 2022, 87, 14565-14579.

DOI: 10.1021/acs.joc.2c01960

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Abstract

Visible light mediates a metal-free oxygenation of quinoxalin-2(1H)-one to quinoxaline-2,3-diones in very good yields by employing Mes-Acr-MeClO₄ as a photocatalyst without using any additive or cocatalyst. O₂ serves as the eco-friendly and green oxidant source for this conversion. In addition, this sustainable approach tolerates a broad range of functional groups.

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proposed mechanism

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Key Words

quinoxalinediones, oxygen, photochemistry, organocatalysis

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ID: J42-Y2022