Electrochemically Mediated Carboxylative Cyclization of Allylic/Homoallylic Amines with CO₂ at Ambient Pressure

Yong-Zhou Pan, Qiang Xia, Jin-Xiu Zhu, Ying-Chun Wang, Ying Liang, Hengshan Wang*, Hai-Tao Tang* and Ying-Ming Pan*

*School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, P.R. China, Email: hshwangmailbox.gxnu.edu.cn, httanggxnu.edu.cn, panymmailbox.gxnu.edu.cn

Y.-Z. Pan, Q. Xia, J.-X. Zhu, Y.-C. Wang, Y. Liang, H. Wang, H.-T. Tang, Y.-M. Pan, Org. Lett., 2022, 24, 8239-8243.

DOI: 10.1021/acs.orglett.2c03377

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Abstract

An electrochemically mediated carboxylative cyclization of allylic amines with CO₂ provdies 2-oxazolidinones. As opposed to previous addition reactions, the unsaturated double bonds are preserved. Furthermore, this method can also be applied to the synthesis of six-membered heterocycles (1,3-oxazinan-2-ones).

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proposed mechanism

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Key Words

oxazolidinones, electrochemistry

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ID: J54-Y2022