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Cobalt-Catalyzed Effective Access to Quinoxalines with Insights in Annulation of Terminal Alkynes and o-Phenylenediamines

Hui-Ru Yang, Zhe-Yao Hu, Xin-Chang Li, Ling Wu and Xun-Xiang Guo*

*Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China, Email:

H.-R. Yang, Z.-Y. Hu, X.-C. Li, L. Wu, X.-X. Guo, Org. Lett., 2022, 24, 8392-8396.

DOI: 10.1021/acs.orglett.2c03465

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The combination of a cobalt catalyst and oxygen as a terminal oxidant mediates an annulation of terminal alkynes and o-phenylenediamines. This method shows wide substrate scope and good functional group tolerance and provides a wide range of quinoxalines in good yields.

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Key Words

quinoxalines, oxygen

ID: J54-Y2022