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Photoredox-Ni Dual Catalysis: Chelation-Free Hydroacylation of Terminal Alkynes

Vetrivelan Murugesan, Anjana Muralidharan, Guru Vigknesh Anantharaj, Tamilselvi Chinnusamy and Ramesh Rasappan*

*School of Chemistry, Indian Institute of Science Education and Research Thiruvananthapuram, Vithura, Thiruvananthapuram, Kerala 695551, India, Email:

V. Murugesan, A. Muralidharan, G. V. Anantharajm, T. Chinnusamy, R. Rasappan, Org. Lett., 2022, 24, 8435-8440.

DOI: 10.1021/acs.orglett.2c03481


Hydroacylation of alkynes is undoubtedly the simplest and most atom-efficient approach for the synthesis of enones. A synergistic nickel-photocatalytic system enables a highly regio- and stereoselective hydroacylation of unactivated aldehydes and alkynes under mild conditions.

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proposed mechanism

Key Words

enones, photochemistry

ID: J54-Y2022