Photoredox-Ni Dual Catalysis: Chelation-Free Hydroacylation of Terminal Alkynes
Vetrivelan Murugesan, Anjana Muralidharan, Guru Vigknesh Anantharaj, Tamilselvi Chinnusamy and Ramesh Rasappan*
*School of Chemistry, Indian Institute of Science Education and Research Thiruvananthapuram, Vithura, Thiruvananthapuram, Kerala 695551, India,
Email: rr
iisertvm.ac.in
V. Murugesan, A. Muralidharan, G. V. Anantharajm, T. Chinnusamy, R. Rasappan, Org. Lett., 2022, 24, 8435-8440.
DOI: 10.1021/acs.orglett.2c03481
Abstract
Hydroacylation of alkynes is undoubtedly the simplest and most atom-efficient approach for the synthesis of enones. A synergistic nickel-photocatalytic system enables a highly regio- and stereoselective hydroacylation of unactivated aldehydes and alkynes under mild conditions.
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proposed mechanism
Key Words
enones, photochemistry
ID: J54-Y2022
