Cobalt-Catalyzed Nitrogen Atom Insertion in Arylcycloalkenes

Juanjuan Wang, Hong Lu, Yi He, Chunxiu Jing and Hao Wei*

*College of Chemistry & Materials Science, Northwest University, Xi’an 710069, China, Email: haownwu.edu.cn

J. Wang, H. Lu, Y. He, C. Jing, H. Wei, J. Am. Chem. Soc., 2022, 144, 22433-22439.

DOI: 10.1021/jacs.2c10570

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Abstract

A simple skeletal editing protocol "inserts" a nitrogen atom into arylcycloalkenes to form the corresponding N-heterocycles. The use of an inexpensive cobalt catalyst under aqueous and open-air conditions makes this protocol very practical. Examples include late-stage modification of compounds of pharmaceutical interest and complex fused ring compounds.

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proposed mechanism

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Key Words

pyridines, air

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ID: J48-Y2022