Ni(I)-Catalyzed Hydroxylation of Aryl Halides with Water under Thermal Catalysis
Liu Yang, Yonggang Yan, Ni Cao, Jing Hao, Gang Li, Wei Zhang, Rui Cao, Chao Wang, Jianliang Xiao and Dong Xue*
*School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an, 710119, China,
Email: xuedong_welcome
snnu.edu.cn
L. Yang, Y. Yan, N. Cao, J. Hao, G. Li, W. Zhang, R. Cao, C. Wang, J. Xiao, D. Xue, Org. Lett., 2022, 24, 9431-9435.
DOI: 10.1021/acs.orglett.2c03840
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Abstract
The combination of a Ni catalyst and PhSiH3 promotes a highly efficient hydroxylation of (hetero)aryl halides using water as a hydroxyl source to provide diverse multifunctional pharmaceutically phenols and polyphenols.
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proposed mechanism
Key Words
ID: J54-Y2022
