Organic Chemistry Portal



DBU-Catalyzed Aerobic CDC Reaction of Thiophenols

Xuemin Jia, Xiao Ma, Wei Feng, Ji-Quan Zhang, Yonglong Zhao, Bing Guo, Lei Tang* and Yuan-Yong Yang*

*School of Pharmacy, Guizhou Medical University, 550014 Guiyang, P. R. China, Email:,

X. Jia, X. Ma, W.-F. J.-Q. Zhang, Y. Zhao, B. Guo, L. Tang, Y.-Y. Yang, J. Org. Chem., 2022, 87, 16492-16505.

DOI: 10.1021/acs.joc.2c02207

see article for more reactions


An environmentally friendly and operationally simple DBU-catalyzed aerobic cross-dehydrogenative coupling (CDC) reaction provides thiolated products of (hetero)aryl acetates, (hetero)aryl ketones, and indoles in good yields.

see article for more examples

proposed mechanism

Key Words

aryl sulfides, sulfides, oxygen

ID: J42-Y2022