Asymmetric Reductive Amination with Pinacolborane Catalyzed by Chiral SPINOL Borophosphates
Zhenwei Wu, Hualing He, Minglei Chen, Linfei Zhu, Weitao Zheng, Yang Cao* and Jon C. Antilla*
*Jiangsu Ocean University, Lianyungang, Jiangsu 222005;
Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, P. R. China, Email:
2020000088
jou.edu.cn, jantillazstu.edu.cn
Z. Wu, H. He, M. Chen, L. Zhu, W. Zheng, Y. Cao, J. C. Antilla, Org. Lett., 2022, 24, 9436-9441.
DOI: 10.1021/acs.orglett.2c03866
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Abstract
SPINOL-derived borophosphates catalyze an asymmetric reductive amination of ketones with pinacolborane to provide a series of chiral amine derivatives bearing multiple functional groups in very good yields and enantioselectivities under mild reaction conditions.
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proposed transition state
Key Words
reductive amination, benzylic amines, pinacolborane, organocatalysis
ID: J54-Y2022
