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Sn(OTf)2-Catalyzed Allylic Substitution of Thiols to Allyl Alcohols: Access to Allyl Sulfides

Yibo Chen, Zhenbo Gao*

*Jiangsu Key Laboratory of Pesticide Science, Department of Chemistry, College of Sciences, Nanjing Agricultural University, Nanjing 210095, China, Email: zgaonjau.edu.cn

Y. Chen, Z. Gao, Synthesis, 2022, 54, 5291-5299.

DOI: 10.1055/s-0041-1738424



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Abstract

Sn(OTf)2 catalyzes a mild and efficient synthesis of allyl sulfides from allyl alcohols and thiols as substrates in dichloromethane at room temperature. A diverse range of allyl sulfides have been obtained with good to excellent yields after a reaction time of 12 hours.


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Key Words

allyl alcohols, allyl sulfides, allylic substitution, C-S bond formation, thiols


ID: J66-Y2022