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Preparation of 4-Arylthiazol-2(3H)-ones and the Three-Component Synthesis of Multidentate 5,5'-Methylenebis[4-arylthiazol-2(3H)-one] Ligands

Juan F. Ortuńo, Samet Poyraz, Asmaa Belabbes, Özge Kavas, Samet Belveren, Cevher Altuğ, María de Gracia Retamosa, Francisco Foubelo, Christopher M. Pask, José M. Sansano, H. Ali Döndaş*

*Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Çukurova, University, Balcalı 01330, Adana, Turkey, Email:

J. F. Ortuńo, S. Poyraz, A. Belabbes, Ö. Kavas, S. Belveren, C. Altuğ, M. de Gracia Retamosa, F. Foubelo, C. M. Pask, J. M. Sansano, H. A. Döndaş, Synthesis, 2023, 55, 141-149.

DOI: 10.1055/a-1930-6840

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A mild methodology provides 4-arylthiazol-2(3H)-ones and 5,5'-methylenebis[4-arylthiazol-2(3H)-ones] using benign solvents. Products can be isolated using a precipitation-recrystallization protocol. The overall methodology can be scaled up to pilot plant level.

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Key Words

thiazolones, N-heterocycles, S-heterocycles, methylenebis(thiazolones), multicomponent reactions

ID: J66-Y2023