Re₂O₇/HReO₄ Mediated Intramolecular Hydroacyloxylation of Unactivated Alkenes: A Dual Hydrogen-Bonding Effect

Yibing Liu, Liqun Hu, Yuzhu Zheng, Xiong Fang and Youwei Xie*

*School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan 430074, China, Email: xieywhust.edu.cn

Y. Liu, L. Hu, Y. Zheng, X. Fang, Y. Xie, Org. Lett., 2023, 25, 64-69.

DOI: 10.1021/acs.orglett.2c03846

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Abstract

The use of Re₂O₇ in hexafluoroisopropanol (HFIP) enables an activation of inert as well as electronically deactivated olefins to facilitate a challenging intramolecular hydroacyloxylation reaction to provide various γ- and δ-lactones in good yields.

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proposed mechanism

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Key Words

lactones

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ID: J54-Y2023