Organic Chemistry Portal



Rh(III)-Catalyzed Oxidative C-H Activation/Annulation of Salicylaldehydes with Masked Enynes for the Synthesis of Chromones

Bo Li, Jianping Zhu, Xia Zheng, Wenqing Ti, Yue Huang* and Hequan Yao*

*China Pharmaceutical University, Nanjing 210009, P. R. China, Email:,

B. Li, J. Zhu, X. Zheng, W. Ti, Y. Huang, H. Yao, J. Org. Chem., 2023, 88, 548-558.

DOI: 10.1021/acs.joc.2c02557

see article for more reactions


A regioselective rhodium(III)-catalyzed oxidative C-H activation/annulation of salicylaldehydes with propargylic acetates provides 3-vinyl chromones in good yields with broad functional group tolerance. 3-Vinyl chromones were converted into biologically active benzo[c]xanthones by I2-mediated oxidative electrocyclization.

see article for more examples

Key Words

chromones. BQ

ID: J42-Y2023