Organic Chemistry Portal

Abstracts

Search:

Rapid Access to Functionalized γ-Lactams through Copper-Catalyzed Oxidative Cyclization of Diynes

Ting-Ting Zhang, Kua-Fei Wei, Guang-Xin Ru, Xiu-Hong Zhu, Li-Xia Xie*, Wen-Bo Shen*

*College of Sciences and College of Forestry, Henan Agricultural University, Zhengzhou 450002, P. R. of China, Email: wenboshenhenau.edu.cn, henauxlxhenau.edu.cn

T.-T. Zhang, K.-F. Wei, G.-X. Ru, X.-H. Zhu, L-X. Xie, W.-B. Shen, Synlett, 2023, 34, 149-152.

DOI: 10.1055/a-1957-4104


see article for more reactions

Abstract

An efficient copper-catalyzed oxidative cyclization of diynes as readily available substrates provides a range of functionalized γ-lactams. This copper-catalyzed oxidative process proceeds through an alkyne oxidation, carbene/alkyne metathesis, and donor-donor carbene oxidation sequence. This simple method offers high flexibility and mild reaction conditions.


see article for more examples



Key Words

3-pyrrolin-2-ones, copper catalysis, diynes, oxidation, pyridine N-oxides, carbene/alkyne metathesis


ID: J72-Y2023