Rapid Access to Functionalized γ-Lactams through Copper-Catalyzed Oxidative Cyclization of Diynes
Ting-Ting Zhang, Kua-Fei Wei, Guang-Xin Ru, Xiu-Hong Zhu, Li-Xia Xie*, Wen-Bo Shen*
*College of Sciences and College of Forestry, Henan
Agricultural University, Zhengzhou 450002, P. R. of China, Email: wenboshenhenau.edu.cn,
henauxlx
henau.edu.cn
T.-T. Zhang, K.-F. Wei, G.-X. Ru, X.-H. Zhu, L-X. Xie, W.-B. Shen, Synlett, 2023, 34, 149-152.
DOI: 10.1055/a-1957-4104
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Abstract
An efficient copper-catalyzed oxidative cyclization of diynes as readily available substrates provides a range of functionalized γ-lactams. This copper-catalyzed oxidative process proceeds through an alkyne oxidation, carbene/alkyne metathesis, and donor-donor carbene oxidation sequence. This simple method offers high flexibility and mild reaction conditions.
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Key Words
3-pyrrolin-2-ones, copper catalysis, diynes, oxidation, pyridine N-oxides, carbene/alkyne metathesis
ID: J72-Y2023