Zn(II)-Catalyzed Selective N-Alkylation of Amines with Alcohols Using Redox Noninnocent Azo-Aromatic Ligand as Electron and Hydrogen Reservoir
Subhajit Chakraborty, Rakesh Mondal, Subhasree Pal, Amit Kumar Guin, Lisa Roy* and Nanda D. Paul*
*Institute of Chemical Technology Mumbai, Bhubaneswar 751013; Institute of Engineering Science and Technology, Howrah 711103, India, Email: l.royiocb.ictmumbai.edu.in, ndpaulgmail.com
S. Chakraborty, R. Mondal, S. Pal, A. J. Guin, L. Roy, N. D. Paul, J. Org. Chem., 2023, 88, 771-787.
DOI: 10.1021/acs.joc.2c01773
see article for more reactions
Abstract
A well-defined Zn(II)-complex catalyzes a sustainable and eco-friendly N-alkylation of various amines by alcohols in very good yields. The method shows wide functional group tolerance and produces the precursors in high yields for the marketed drugs tripelennamine and thonzonium bromide in gram-scale reactions.
see article for more examples
A. K. Guin, S. Pal, S. Chakraborty, S. Chakraborty, N. D. Paul, J. Org. Chem., 2023, 88, 5944-5961.
Key Words
ID: J42-Y2023