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Metal-Free Synthesis of Thiocyanated Aminonitroalkenes and 2-Aminothiazoles/selenazoles from β-Aminonitroalkenes and N-Thio/Selenocyanatosaccharin

Hongchen Yang, Yuce Chen, Xiaoyong Xu, Zhong Li*

*Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, P. R. of China, Email: lizhongecust.edu.cn

H. Yang, Y. Chen, X. Xu, Z. Li, Synlett, 2023, 34, 176-182.

DOI: 10.1055/a-1929-2515


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Abstract

A metal-free synthesis of thiocyanated aminonitroalkenes and 2,4,5-trisubstituted thiazoles/selenazoles from β-aminonitroalkenes and N-thio/selenocyanatosaccharin offers simple operation, mild reaction conditions, short reaction time, and good functional group compatibility.


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Key Words

thiazoles, 2-aminothiazoles, β-aminonitroalkenes, N-thiocyanatosaccharin


ID: J72-Y2023