Synthesis of Quinoline-2-thiones by Selective Deoxygenative C-H/C-S Functionalization of Quinoline N-Oxides with Thiourea
Dmitry I. Bugaenko*, Olga A. Tikhanova and Alexander V. Karchava*
*Department of Chemistry, Moscow State University, Moscow 119991, Russia,
Email: bugaenkoorg.chem.msu.ru, karchava
org.chem.msu.ru
D. I. Bugaenko, O. A. Tikhanova, A. V. Karchava, J. Org. Chem., 2023, 88, 1018-1023.
DOI: 10.1021/acs.joc.2c02433
see article for more reactions
Abstract
A regioselective deoxygenative C-H functionalization of readily available quinoline-N-oxides with thiourea upon activation with triflic anhydride enable the synthesis of quinoline-2-thiones in very good yields.
see article for more examples
Key Words
benzo-fused N-heterocycles, 2-quinolones
ID: J42-Y2023