Synthesis of 2,4,5-Trisubstituted Oxazoles from Copper-Mediated Benzylic sp³ C-H Aerobic Oxidative Annulation of Ketones and Amines via a Cascade Reaction

Mncedisi Mazibuko and Vineet Jeena*

*School of Chemistry and Physics, University of KwaZulu-Natal, Scottsville, Pietermaritzburg 3209, South Africa, Email: Jeenav1ukzn.ac.za

M. Mazibuko, V. Jeena, J. Org. Chem., 2023, 88, 1227-1234.

DOI: 10.1021/acs.joc.2c02148

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Abstract

An oxidative, copper-catalyzed, and solvent-free annulation enables a facile synthesis of 2,4,5-triarylated oxazoles at a mild temperature from readily available substrates under an atmosphere of molecular oxygen.

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Key Words

oxazoles, oxygen

ID: J42-Y2023

Synthesis of 2,4,5-Trisubstituted Oxazoles from Copper-Mediated Benzylic sp3 C-H Aerobic Oxidative Annulation of Ketones and Amines via a Cascade Reaction

Mncedisi Mazibuko and Vineet Jeena*

Synthesis of 2,4,5-Trisubstituted Oxazoles from Copper-Mediated Benzylic sp³ C-H Aerobic Oxidative Annulation of Ketones and Amines via a Cascade Reaction