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Oxidative Dehydrogenative Coupling of Thiols with Alkanes for the Synthesis of Sulfoxides

Yu-Jian Hou, Yi Li, Zhi-Wei Zhao, Tai-Gang Fan, Bo-Xun Sun, Xu-Nan Wang and Ya-Min Li*

*Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, P. R. China, Email:

Y.-J. Hou, Y. Li, Z.-W. Zhao, T.-G. Fan, B.-X. Sun, X.-N. Wang, Y.-M. Li, Org. Lett., 2023, 25, 517-521.

DOI: 10.1021/acs.orglett.2c04238

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An oxidative dehydrogenative coupling of thiols with alkanes provides an efficient access to sulfoxides via direct C(sp3)-H bond functionalization. The present reaction features the use of readily available reagents and high step- and atom-efficiency, thus  A possible mechanism is proposed.

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proposed mechanism

Key Words

sulfoxides (oxidation, coupling), benzoyl peroxide

ID: J54-Y2023