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Chromium-Catalyzed Defluorinative Reductive Coupling of Aldehydes with gem-Difluoroalkenes

Yu-Tao Liu, Yu-Hang Fan, Yan Mei, Dong-Jie Li, Yan Jiang, Wen-Hao Yu* and Fei Pan*

*College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610068, People's Republic of China, Email: yuwenhaosicnu.edu.cn, feipansicnu.edu.cn

Y.-T. Liu, Y.-H. Fan, Y. Mei, D.-J. Li, Y. Jiang, W.-H. Yu, F. Pan, Org. Lett., 2023, 25, 549-554.

DOI: 10.1021/acs.orglett.3c00016


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Abstract

A mild and convenient defluorinative reductive cross coupling of gem-difluoroalkenes with aliphatic aldehydes provides diverse β-fluorinated allylic alcohols in good yields. The reaction is operationally simple and shows good functional group tolerance.

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proposed mechanism



Key Words

allylic alcohols, manganese


ID: J54-Y2023