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Selective Fluorosulfonylation of Thianthrenium Salts Enabled by Electrochemistry

Xianqiang Kong*, Yiyi Chen, Qianwen Liu, WenJie Wang, Shuangquan Zhang, Qian Zhang, Xiaohui Chen, Yuan-Qing Xu and Zhong-Yan Cao*

*Changzhou Institute of Technology, No. 666 Liaohe Road, Changzhou 213032; Henan University, Kaifeng 475004, China, Email: kongxqczu.cn, zycaohenu.edu.cn

X. Kong, Y. Chen, Q. Liu, W. Wang, S. Zhang, Q. Zhang, X. Chen, Y.-Q. Xu, Z.-Y. Cao, Org. Lett., 2023, 25, 581-586.

DOI: 10.1021/acs.orglett.2c03956


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Abstract

A practical electrochemically method for fluorosulfonylation of both aryl and alkyl thianthrenium salts works without external redox reagents or metal catalysts. In combination with C-H thianthrenation of aromatics, this method provides an interesting tool for the site-selective fluorosulfonylation of drugs.

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Key Words

fluorosulfonylation, electrochemistry


ID: J54-Y2023