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A Neutral FeCl3 Photocatalysis for C-C Bond Animation and Alkylation of Cyclic Alcohols

Zongnan Zhang, Ting Xue, Zhe Han, Rong Zeng*

*School of Chemistry, Xi’an Jiaotong University, Xi’an 710049, P. R. of China, Email:

Z. Zhang, T. Xue, Z. Han, R. Zeng, Synthesis, 2023, 55, 433-442.

DOI: 10.1055/a-1966-3271

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Using FeCl3 as catalyst, a photoinduced ligand-to-metal charge transfer facilitates the generation of O-radicals from nonactivated cyclic alcohols, a subsequent β-scission, and finally a radical trapping. This mildly base-free system enables an amination of a broad substrate scope with high yields.

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Key Words

iron catalysis, photochemistry, C-C bond cleavage, hydrazine derivatives, amination, alkylation

ID: J66-Y2023