Synthesis of 3-Haloindoles via Cascade Oxidative Cyclization/Halogenation of 2-Alkenylanilines Mediated by PIDA and LiBr/KI
Bingyue Zhao, Xiaoxian Li, Xiaofan Wang, Luchen Jiang, Zhe Li and Yunfei Du*
*School of Pharmaceutical Science and Technology, Tianjin
University, Tianjin 300072, China, Email: duyunfeiertju.edu.cn
B. Zhao, X. Li, X. Wang, L. Jiang, Z. Li, Y. Du, J. Org. Chem., 2023, 88, 1493-1503.
DOI: 10.1021/acs.joc.2c02480
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Abstract
Treatment of 2-alkenylanilines with phenyliodine(III) diacetate (PIDA) and LiBr or KI in HFIP provides the corresponding 3-bromoindoles and 3-iodoindoles via cascade oxidative cyclization/halogenation.
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proposed mechanisms
Key Words
ID: J42-Y2023