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In Situ Hypoiodite-Catalyzed Oxidative Rearrangement of Chalcones: Scope and Mechanistic Investigation

Meiqiong Zheng, Chao Huang, Jian-Zhong Yan, Shu-Li Xie, Shao-Jia Ke, Hai-Dong Xia* and Ya-Nan Duan*

*Chemistry and Chemical Engineering Guangdong Laboratory, Shantou 515031, P. R. China, Email: xhd198896126.com, duanyanan008_work163.com

M. Zheng, C. Huang, J.-Z. Yan, S.-L. Xie, S.-J. Ke, H.-D. Xia, Y.-N. Duan, J. Org. Chem., 2023, 88, 1504-1514.

DOI: 10.1021/acs.joc.2c02291



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Abstract

In situ generated hypoiodite catalyzes an oxidative rearrangement of chalcones under mild and metal-free conditions. This environmental-benign protocol avoids the use of rare or toxic metals.

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proposed mechanisms



Key Words

α-arylation, acetals, 1,3-diketones, mCPBA


ID: J42-Y2023