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Hydrido-Cobalt Complexes for the Chemo- and Regioselective 1,2-Silylative Dearomatization of N-Heteroarenes

Cassandre C. Bories, Geoffrey Gontard, Marion Barbazanges, Etienne Derat and Marc Petit*

*Sorbonne Université, CNRS, Institut Parisien de Chimie Moléculaire, UMR 8232, 4 Place Jussieu, 75005 Paris, France, Email:

C. C. Bories, G. Gontard, M. Barbazanges, E. Derat, M. Petit, Org. Lett., 2023, 25, 843-848.

DOI: 10.1021/acs.orglett.3c00022

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An efficient regio- and chemoselective dearomatization of a wide range of N-heteroarenes using hydrido-cobalt catalysts can be performed under mild conditions. Various quinolines and pyridines bearing electron-donating and electron-withdrawing substituents are compatible with this methodology.

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proposed mechanism

Key Words

1,2-dihydroquinolines, phenylsilane

ID: J54-Y2023