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Fe-Catalyzed Direct Synthesis of Nitriles from Carboxylic Acids with Electron-Deficient N-Cyano-N-aryl-arylsulfonamide

Guodong Zhang*, Chengyu Zhang, Ye Tian and Feng Chen*

*School of Chemistry and Chemical Engineering, Yangzhou University, Siwangting Road 180, 225002 Yangzhou, China, Email:,

G. Zhang, C. Zhang, Y. Tian, F. Chen, Org. Lett., 2023, 25, 917-922.

DOI: 10.1021/acs.orglett.2c04185

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An inexpensive iron catalyst promotes a reaction of ubiquitous carboxylic acids with electron-deficient N-cyano-N-aryl-arylsulfonamide to provide diverse nitrile compounds in good yields. This strategy enables the conversion of alkyl and aryl carboxylic acids, and tolerates a variety of functional groups.

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proposed mechanism

Key Words


ID: J54-Y2023