Catalyst-Free Synthesis of Phosphorothioates via P-S Coupling Reaction of Dialkyl Phosphites with Thiols
Babak Kaboudin*, Payam Daliri, Hesam Esfandiari, Foad Kazemi
*Department of Chemistry, Institute for Advanced Studies, in
Basic Sciences (IASBS), Zanjan 45137-66731, Iran, Email: kaboudin
iasbs.ac.ir
B. Kaboudin, P. Daliri, H. Esfandiari, F. Kazemi, Synlett, 2023, 34, 249-252.
DOI: 10.1055/a-1983-1640
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Abstract
A convenient reaction of thiols with H-dialkyl phosphites in the presence of DMSO as both solvent and oxidant provides various phosphorothioates under transition-metal-free conditions. The reaction proceeds with formation of a disulfide intermediate followed by nucleophilic substitution with the dialkyl phosphite.
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Key Words
ID: J72-Y2023
