Visible-Light-Mediated Deacylated Alkynylation of Unstrained Ketone
Hao Wu, Shuguang Chen*, Dengmengfei Xiao, Feng Li, Kaiyuan Zhou, Xiaocui Yin, Chunni Liu, Xinwei He and Yongjia Shang*
*College of Chemistry and Materials Science, Anhui Normal
University, Wuhu 241000, P. R. China, Email: csgcss
163.com,
shyjmail.ahnu.edu.cn
H. Wu, S. Chen, D. Xiao, F. Li, K. Zhou, X. Yin, C. Liu, X. He, Y. Shang, Org. Lett., 2023, 25, 1166-1171.
DOI: 10.1021/acs.orglett.3c00145
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Abstract
An organic photocatalyst mediates a deconstructive alkynylation of an unstrained ketone under blue light irradiation. This alkynylation method offers a broad substrate scope and excellent functional group tolerance. A trifluoromethylation reagent for the trifluoromethylation reaction of various alkynyl bromides is also described.
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4CzIPN
Key Words
alkynylation, trifluoromethylation, photochemistry, organocatalysis
ID: J54-Y2023
