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CuF2/DMAP-Catalyzed N-Vinylation: Scope and Mechanistic Study

Krishanu Mondal, Susanta Patra, Pallabi Halder, Narottam Mukhopadhyay and Parthasarathi Das*

*Department of Chemistry and Chemical Biology, Indian Institute of Technology (Indian School of Mines), Dhanbad 826004, India, Email: parthaiitism.ac.in

K. Mondal, S. Patra, P. Halder, N. Mukhopadhyay, P. Das, Org. Lett., 2023, 25, 1235-1240.

DOI: 10.1021/acs.orglett.2c03856


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Abstract

CuF2/DMAP is as an excellent catalytic system for vinylsilane-promoted N-vinylation of amides and azoles at room temperature without an external fluoride source. Valuable monomers for water-soluble polymers, viz., NVP, NVC, and NVIBA, were synthesized on a gram scale.

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proposed mechanism



Key Words

enamides, oxygen


ID: J54-Y2023