Cooperative Isothiourea/Iridium-Catalyzed Asymmetric Annulation Reactions of Vinyl Aziridines with Pentafluorophenyl Esters
Qiannan Wang, Tao Fan and Jin Song*
*Institutes of Physical Science and Information Technology, Key Laboratory of Environment-Friendly Polymeric Materials of Anhui Province, Anhui
University, Hefei 230601, China, Email: jill
ahu.edu.cn
Q. Wang, T. Fan, J. Song, Org. Lett., 2023, 25, 1246-1251.
DOI: 10.1021/acs.orglett.2c04124
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Abstract
A chiral isothiourea and an Ir complex cooperatively catalyze [3 + 2] asymmetric annulation reactions of vinyl aziridines with pentafluorophenyl esters to provide a broad range of optically active γ-lactams in good yields with high asymmetric induction.
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proposed mechanism
Key Words
ID: J54-Y2023
