Organic Chemistry Portal

Abstracts

Search:

Nickel-Catalyzed Negishi Cross-Coupling of Alkyl Halides, Including Unactivated Tertiary Halides, with a Boron-Stabilized Organozinc Reagent

Panchi Guo, Hao Jin, Jinhui Han, Liang Xu, Pengfei Li* and Miao Zhan*

*Xi'an Jiaotong University, 99 Yanxiang Road, Xi'an 710054; Northwestern Polytechnical University, 127 West Youyi Road, Xi'an 710072, China, Email: lipengfeixjtu.edu.cn, mzhan@nwpu.edu.cn

P. Guo, H. Jin, J. Han, L. Xu, P. Li, M. Zhan, Org. Lett., 2023, 25, 1246-1251.

DOI: 10.1021/acs.orglett.3c00051



see article for more reactions

Abstract

A nickel-catalyzed Negishi cross-coupling of alkyl halides, including unactivated tertiary halides, with the boron-stabilized organozinc reagent BpinCH2ZnI provides versatile organoboron products with high functional-group tolerance.

see article for more examples



Key Words

Negishi coupling, alkylboronates, C-C cross coupling


ID: J54-Y2023