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Chemoselective Strain Release of Bicyclo[1.1.1]pent-1-yl Alcohols

Yue Ma, Yinan Ai, Songjie Yu*

*Institute of Molecular Science and Engineering, Institute of Frontier and Interdisciplinary Sciences, Shandong University, Qingdao, 266237, P. R. of China, Email: yusongjie08mails.ucas.ac.cn

Y. Ma, Y. Ai, S. Yu, Synlett, 2023, 34, 149-152.

DOI: 10.1055/a-1992-6707


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Abstract

Chemoselective C-C bond cleavages of reactive bicyclo[1.1.1]pent-1-yl alcohols (BCP-OHs) provide cyclobutanone derivatives through a base-mediated single C-C bond cleavage or α,β-unsaturated ketones by palladium-catalyzed dual C-C bond cleavage.

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Key Words

cyclobutanones, enones


ID: J72-Y2023