NHPI-Mediated Electrochemical α-Oxygenation of Amides to Benzimides

Fang Bai, Ning Wang, Yinshan Bai, Xiaowei Ma, Chengzhi Gu*, Bin Dai and Jianpeng Chen

*School of Chemistry and Chemical Engineering, Shihezi University, Xinjiang Uygur Autonomous Region 832000, China, Email: gcz_teashzu.edu.cn

F. Bai, N. Wang, Y. Bai, X. Ma, C. Gu, B. Dai, J. Chen, J. Org. Chem., 2023, 88, 2985-2998.

DOI: 10.1021/acs.joc.2c02700

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Abstract

N-Hydroxyphthalimide (NHPI) mediates a mild electrochemical α-oxygenation of a wide range of linear and cyclic benzamides in an undivided cell using O₂ as the oxygen source and 2,4,6-trimethylpyridine perchlorate as an electrolyte.

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Key Words

imides, oxygen, electrochemistry

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ID: J42-Y2023