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Arylation of Terminal Alkynes: Transition-Metal-Free Sonogashira-Type Coupling for the Construction of C(sp)-C(sp2) Bonds

Mingxing Ye, Mengyuan Hou, Yahao Wang, Xingxing Ma, Kai Yang and Qiuling Song*

*Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry at Fuzhou University, Fujian Province University, Fuzhou, Fujian 350108, P. R. China, Email:

M. Ye, M. Hou, Y. Wang, X. Ma, K. Yang, Q. Song, Org. Lett., 2023, 25, 1787-1792.

DOI: 10.1021/acs.orglett.3c00586

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NIS mediates a transition-metal-free arylation of terminal alkynes with a tetracoordinate boron intermediate. The reaction offers high efficiency, wide substrate range, and good functional group tolerance.

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proposed mechanism

Key Words

arylation, NIS

ID: J54-Y2023