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Application of Halogen-Bonding Catalysis for Markovnikov-Type Hydrothiolation of Alkenes

Xue Zhang, Nuoyu Liang, Ruining Li, Zhankui Sun*

*School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd., Shanghai 200240, P. R. of China, Email:

X. Zhang, N. Liang, R. Li, Z. Sun, Synlett, 2023, 34, 379-387.

DOI: 10.1055/a-1984-9105

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I2 catalyzes the hydrothiolation of alkenes and provides Markovnikov-type products in very good yields. This metal-free reaction offers green and mild conditions, high functional group tolerance, broad substrate scope, and atom economy.

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Key Words

benzyl sulfides, halogen bonding, hydrothiolation, Markovnikov reaction, alkenes, addition

ID: J72-Y2023