Organic Chemistry Portal



Enantioselective C(sp3)-H Functionalization of Oxacycles via Photo-HAT/Nickel Dual Catalysis

Sheng Xu, Yuanyuan Ping, Wei Li, Haoyun Guo, Yinyan Su, Ziyang Li, Minyan Wang* and Wangqing Kong*

*School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023; Hongyi Honor College, Wuhan University, Wuhan 430072, China Email:,

S. Xu, Y. Ping, W. Li, H. Guo, Y. Su, Z. Li, M. Wang, W. Kong, J. Am. Chem. Soc., 2023, 145, 5231-5241.

DOI: 10.1021/jacs.2c12481

see article for more reactions


An enantioselective C(sp3)-H functionalization of undirected oxacycles via photo-HAT/nickel dual catalysis enables the rapid construction of enantiomerically enriched oxacycles directly from simple and abundant hydrocarbon feedstocks. The synthetic utility is demonstrated in the late-stage functionalization of natural products and the synthesis of pharmaceutically relevant molecules.

see article for more examples

proposed mechanism

Key Words

tetrahydrofurans, photochemistry

ID: J48-Y2023