Organic Chemistry Portal



Construction of C(CO)-C(CO) Bond via NHC-Catalyzed Radical Cross-Coupling Reaction

Hai-Bin Yang*, Xiao-Fang Jin, Hui-Ying Jiang and Wenwei Luo*

*Guangdong University of Technology, Guangzhou 510006; Southern Medical University, Guangzhou 510080, China, Email:,

H.-B. Yang, X.-F. Jin, H. Y. Jiang, W. Luo, Org. Lett., 2023, 25, 1829-1833.

DOI: 10.1021/acs.orglett.3c00272

see article for more reactions


A photoredox/NHC cocatalyzed decarboxylative acylation of oxamic acid with acyl fluoride provides a variety of useful α-keto amides, including sterically congested ones, under mild conditions via a two-component radical cross-coupling reaction.

see article for more examples

proposed mechanism

Key Words

α-keto amides

ID: J54-Y2023