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Utilization of Aryl(TMP)iodonium Salts for Copper-Catalyzed N-Arylation of Isatoic Anhydrides: An Avenue to Fenamic Acid Derivatives and N,N'-Diarylindazol-3-ones

Raktim Abha Saikia, Khanindra Talukdar, Debabrat Pathak, Bipul Sarma and Ashim Jyoti Thakur*

*Department of Chemical Sciences, Tezpur University, Napaam 784028, India, Email: ashimtezu.ernet.in

R. A. Saikia, K. Talukdar, D. Pathak, B. Sarma, A. J. Thakur, J. Org. Chem., 2023, 88, 3567-3581.

DOI: 10.1021/acs.joc.2c02762



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Abstract

Copper catalyzes a mild and operationally simple N-arylation of isatoic anhydrides with aryl(TMP)iodonium trifluoroacetates in good yields at room temperature. Alternative one-pot approaches for biologically relevant fenamic acid derivatives and N,N'-diarylindazol-3-ones are reported too.

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proposed mechanism



Key Words

benzo-fused N-heterocycles, benzo-fused O-heterocycles


ID: J42-Y2023