Reduction of Triphenylphosphine Oxide to Triphenylphosphine by Phosphonic Acid
Jing Xiao*, Jie Wang, Huimin Zhang, Jianqiu Zhang and Li-Biao Han*
*Hunan University of Science and Technology, Xiangtan 411201; Hainan University, Haikou 570228, China,
Email: XiaoJing
hnust.edu.cn, hlbshoufuchem.com
J. Xiao, J. Wang, H. Zhang, J. Zhang, L.B. Han, J. Org. Chem., 2023, 88, 3909-3915.
DOI: 10.1021/acs.joc.2c02807
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Abstract
Iodine mediates a reduction of phosphine oxides (sulfides) to phosphines using phosphonic acid under solvent-free conditions. Both tertiary monophosphine oxides and bis-phosphine oxides readily produce monodentate and bidentate phosphines, respectively, in good yields and in case of (R)-(+)-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl dioxide without racemization.
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proposed reaction pathway
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Key Words
reduction of phosphine oxides, phosphonic acid
ID: J42-Y2023
