Enantioselective Synthesis of Skipped Dienes via Iridium-Catalyzed Allylic Alkylation of Phosphonates
Arko Seal and Santanu Mukherjee*
*Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, India,
Email: sm
iisc.ac.in
A. Seal, S. Mukherjee, Org. Lett., 2023, 25, 2253-2257.
DOI: 10.1021/acs.orglett.3c00505
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Abstract
An iridium-catalyzed allylic alkylation of phosphonates followed by a Horner-Wadsworth-Emmons olefination provides skipped dienes bearing a C3 stereogenic center, generally with outstanding enantioselectivities.
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Key Words
1,4-dienes, terminal olefins, unsaturated esters, Wittig-Horner reaction
ID: J54-Y2023
