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Palladium-Catalyzed Reductive Formylation of Aryl Iodides with CO2 under Mild Conditions

Dan Li, Li Wei, Wenfang Xiong, Huanfeng Jiang and Chaorong Qi*

*School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China, Email: crqiscut.edu.cn

D. Li, L. Wei, W. Xiong, H. Jiang, C. Qi, J. Org. Chem., 2023, 88, 5231-5237.

DOI: 10.1021/acs.joc.2c02576


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Abstract

The combination of Pd(PCy3)2Cl2 and di-2-pyridyl ketone catalyzes a reductive formylation of aryl iodides with carbon dioxide as the carbonyl source under mild reaction conditions in the presence of phenylsilane as the reductive reagent. This convenient reaction provides a variety of aromatic aldehydes in good yields with wide substrate scope and good functional group tolerance.


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proposed mechanism



Key Words

formylations, phenylsilane


ID: J42-Y2023