Metal-Free Efficient, General and Facile Iododecarboxylation Method with Biodegradable Co-Products
Kseniya Kulbitski, Gennady Nisnevich, Mark Gandelman*
*Schulich Faculty of Chemistry, Technion - Israel Institute of Technology, Technion City, Haifa 32000 Israel,
Email: chmarktx.technion.ac.il
K. Kulbitski, G. Nisnevich, M. Gandelman, Adv. Synth. Catal., 2011, 353, 1438-1442.
DOI: 10.1002/adcs.201100145
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Abstract
An efficient and robust method enables a general conversion of aliphatic and aromatic carboxylic acids to organic iodides without the use of heavy metals or strong oxidizing agents. Commercially available N-iodoamides were used for both initiation and halogen donation under irradiative conditions. Isolation of the product is extremely simple and the major co-product is water-soluble.
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Key Words
Hunsdiecker reaction, DIH, iodoarenes, iodoalkanes, photochemistry
ID: JXX-Y2011