Palladium-Catalyzed Oxidative Amination of Unactivated Olefins with Primary Aliphatic Amines

Mingda Li, Yangbin Jin, Yupeng Chen, Wanqing Wu* and Huanfeng Jiang*

*School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China, Email: cewuwqscut.edu.cn, jianghfscut.edu.cn

M. Li, Y. Jin, Y. Chen, W. Wu, H. Jiang, J. Am. Chem. Soc., 2023, 145, 9448-9453.

DOI: 10.1021/jacs.3c02114

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Abstract

The combination of a palladium catalyst, a bidentate phosphine ligand, and duroquinone enables a catalytic intermolecular oxidative amination of unactivated olefins with primary aliphatic amines provides a range of secondary allylic amines in good yields with excellent regio- and stereoselectivity. The reaction proceeds by allylic C(sp³)-H activation and nucleophilic amination.

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Key Words

allylic amines, duroquinone

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ID: J48-Y2023