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Palladium-Catalyzed Transfer Hydrogenation and Acetylation of N-Heteroarenes with Sodium Hydride as the Reductant

Fan Luo, Xiaobei Chen, Jing Yu, Yuejia Yin, Xiaoxiao Hu, Ying Hu*, Xuejun Liu, Xiaodong Chen, Shilei Zhang*, Yanwei Hu*

*Suzhou Vocational Health College, Suzhou 215009; Soochow University, Suzhou, Jiangsu 215123, P. R. China, Email:,,

F. Luo, X. Chen, J. Yu, Y. Yin, X. Hu, Y. Hu, X. Liu, X. Chen, S. Zhang, Y. Hu, Synthesis, 2023, 55, 1451-1459.

DOI: 10.1055/a-1988-5764

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An efficient and convenient palladium-catalyzed reductive system by employing sodium hydride as the hydrogen donor and acetic anhydride as an activator enables the transfer hydrogenation and acetylation of a wide range of N-heteroarenes including quinoline, phthalazine, quinoxaline, phenazine, phenanthridine, and indole.

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Key Words

palladium, sodium hydride, transfer hydrogenation, tetrahydroquinolines

ID: J66-Y2023