Palladium-Catalyzed Transfer Hydrogenation and Acetylation of N-Heteroarenes with Sodium Hydride as the Reductant
Fan Luo, Xiaobei Chen, Jing Yu, Yuejia Yin, Xiaoxiao Hu, Ying Hu*, Xuejun Liu, Xiaodong Chen, Shilei Zhang*, Yanwei Hu*
*Suzhou Vocational Health College, Suzhou 215009; Soochow
University, Suzhou, Jiangsu 215123, P. R. China, Email: yhuszhct.edu.cn,
zhangshilei
suda.edu.cn, huyanwei
suda.edu.cn
F. Luo, X. Chen, J. Yu, Y. Yin, X. Hu, Y. Hu, X. Liu, X. Chen, S. Zhang, Y. Hu, Synthesis, 2023, 55, 1451-1459.
DOI: 10.1055/a-1988-5764
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Abstract
An efficient and convenient palladium-catalyzed reductive system by employing sodium hydride as the hydrogen donor and acetic anhydride as an activator enables the transfer hydrogenation and acetylation of a wide range of N-heteroarenes including quinoline, phthalazine, quinoxaline, phenazine, phenanthridine, and indole.
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Key Words
palladium, sodium hydride, transfer hydrogenation, tetrahydroquinolines
ID: J66-Y2023