Metal-Catalyst-Controlled Divergent Synthesis of γ-Butyrolactones via Intramolecular Coupling of Epoxides with Alcohols
Feipeng Liu, Zifan Cheng, Yiyun Fang, Xuchao Wang, Lingzi Zhao and Zi-Qiang Rong*
*Northwestern Polytechnical University (NPU), 127 West Youyi Road, Xi’an 710072, China,
Email: iamzqrong
nwpu.edu.cn
F. Liu, Z. Chen, X. Fang, X. Wang, L. Zhao, Z.-Q. Rong, Org. Lett., 2023, 25, 3618-3622.
DOI: 10.1021/acs.orglett.3c00898
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Abstract
An intramolecular coupling of epoxides with alcohols provides α- and β-substituted γ-butyrolactones depending on the transition metal catalyst used. This methods offers an efficient and practicable way to afford γ-butyrolactones with good efficiency, excellent regioselectivity, and broad substrate scope.
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proposed mechanisms
Key Words
ID: J54-Y2023
