Synthesis of α-Aminoacetals via Decarboxylative Coupling of Imine and 2,2,-Diethoxyacetic Acid
Seoksun Kim, Beomsoon Park, Geun Seok Lee and Soon Hyeok Hong*
*Department of Chemistry, Korea Advanced Institute of Science
and Technology (KAIST), Daejeon 34141, Republic of Korea, Email: soonhyeok.hong
kaist.ac.kr
S. Kim, B. Park, G. S. Lee, S. H. Hong, J. Org. Chem., 2023, 88, 6532-6537.
DOI: 10.1021/acs.joc.2c01941
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Abstract
A photocatalytic decarboxylative coupling of imine and 2,2-diethoxyacetic acid in the presence of a nonstoichiometric amount of a radical initiator provides α-aminoacetals. This atom-economical C-C coupling tolerates various functional groups. The diversely functionalized α-aminoacetals serve as a promising platform for further research.
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proposed mechanism
4CzIPN
Key Words
α-amino aldehydes, photochemistry, organocatalysis
ID: J42-Y2023
