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Transamination of Aromatic Aldehydes to Primary Arylmethylamines

Weiqi Cai, Yue Yang, Jiguo Ma, Jing Cao*, Xinyi Ren and Baoguo Zhao*

*Shanghai Frontiers Science Center of Biomimetic Catalysis, Shanghai Normal University, Shanghai 200234, China, Email:,

W. Cai, Y. Yang, J. Ma, J. Cao, X. Ren, B. Zhao, Org. Lett., 2023, 25, 3876-3880.

DOI: 10.1021/acs.orglett.3c01234


In the presence of 2-amino-2-phenylpropanoate salts as the amine source, aromatic aldehydes underwent an efficient decarboxylative transamination under very mild conditions to produce a variety of arylmethylamines in very good yields.

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proposed reaction pathway

Key Words

benzylic amines, primary amines

ID: J54-Y2023