Copper-Catalyzed Decarboxylative Cascade Cyclization for the Synthesis of 2-Arylquinolines
Rana Chatterjee, Mohanreddy Pothireddy, Rambabu Dandela*
*Department of Industrial and Engineering Chemistry,
Institute of Chemical Technology, Indian Oil Odisha Campus, Samantpuri,
Bhubaneswar, 751013, India, Email: r.dandelaiocb.ictmumbai.edu.in
R. Chatterjee, M. Pothireddy, R. Dandela, Synlett, 2023, 34, 1058-1062.
DOI: 10.1055/a-1990-3283
Abstract
An efficient copper-catalyzed intermolecular decarboxylative cascade cyclization of aryl aldehydes, anilines, and acrylic acid permits the direct synthesis of 2-substituted quinolines. This method features promising chemo- and regioselectivity and also tolerates a wide variety of substrates with excellent functional-group tolerance, high yields, a radical reaction pathway, and aerobic reaction conditions.
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Key Words
copper catalysis, oxidative coupling, iodine, multicomponent reactions, cyclization, decarboxylation, quinolines
ID: J72-Y2023