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Copper-Catalyzed Decarboxylative Cascade Cyclization for the Synthesis of 2-Arylquinolines

Rana Chatterjee, Mohanreddy Pothireddy, Rambabu Dandela*

*Department of Industrial and Engineering Chemistry, Institute of Chemical Technology, Indian Oil Odisha Campus, Samantpuri, Bhubaneswar, 751013, India, Email:

R. Chatterjee, M. Pothireddy, R. Dandela, Synlett, 2023, 34, 1058-1062.

DOI: 10.1055/a-1990-3283


An efficient copper-catalyzed intermolecular decarboxylative cascade cyclization of aryl aldehydes, anilines, and acrylic acid permits the direct synthesis of 2-substituted quinolines. This method features promising chemo- and regioselectivity and also tolerates a wide variety of substrates with excellent functional-group tolerance, high yields, a radical reaction pathway, and aerobic reaction conditions.

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Key Words

copper catalysis, oxidative coupling, iodine, multicomponent reactions, cyclization, decarboxylation, quinolines

ID: J72-Y2023