Triflylpyridinium as Coupling Reagent for Rapid Amide and Ester Synthesis
Du Chen, Liangxuan Xu, Bowen Ren, Zian Wang and Chao Liu*
*University of Chinese Academy of Sciences, Beijing 100049, China,
Email: chaoliu
licp.cas.cn
D. Chen, L. Xu, B. Ren, Z. Wang, C. Liu, Org. Lett., 2023, 25, 4571-4575.
DOI: 10.1021/acs.orglett.3c01598
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Abstract
Stable and easily accessible triflylpyridinium reagents mediate an effective synthesis of a broad range of amides and esters at ambient temperature within 5 min. In addition, a flow process enables a scalable synthesis of peptides and esters. Moreover, excellent chirality retentions are presented during activation of carboxylic acid.
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Key Words
ID: J54-Y2023
