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TBAT-Catalyzed Deoxygenative Reduction of Tertiary Amides to Amines

Vinothkumar Vinayagam*, Subir Kumar Sadhukhan, Satish Kumar Karre, Ravuri Srinath, Ravi Kumar Maroju, Purushotham Reddy Karra, Hema Sundar Naveen Babu Bathula, Siva Kundrapu and Srikanth Reddy Surukonti

*Medicinal Chemistry Division, Curia India Pvt. Ltd, MN park, Genome Valley, Turkapally 500078, Hyderabad, India, Email:

V. Vineyagam, S. K. Sadhukhan, S. K. Karre, R. Srinath, R. K. Maroju, P. R. Karra, H. S. N. B. Bathula, S. Kundrapu, S. R. Surukonti, Org. Lett., 2023, 25, 4610-4614.

DOI: 10.1021/acs.orglett.3c01150

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A simple, mild, metal-free catalytic protocol for an efficient conversion of amides to amines at r.t. uses the stable tetrabutylammonium difluorotriphenylsilicate in combination with silanes that generates a highly reactive hydrosilicate species. The attractive features of this protocol include operational simplicity, safety, broad substrate scope, good yields, and amenable to scale up.

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proposed mechanism

Key Words

reduction of amides, phenylsilane

ID: J54-Y2023