Asymmetric Biomimetic Transamination of Trifluoromethyl Ketones
Weiqi Cai, Dongchen Cai, Hanyu Liang, Xinyi Ren and Baoguo Zhao*
*Shanghai Frontiers Science Center of Biomimetic Catalysis, Shanghai Normal University, Shanghai 200234, China,
Email: zhaobg2006
shnu.edu.cn
W. Cai, D. Cai, H. Liang, X. Ren, B. Zhao, J. Org. Chem., 2023, 88, 7849-7857.
DOI: 10.1021/acs.joc.2c02329
see article for more reactions
Abstract
A chiral pyridoxamine catalyzes an asymmetric biomimetic transamination of trifluoromethyl ketones with 2,2-diphenylglycine as the amine source to produce optically active α-trifluoromethyl amines in very good yields with excellent ee's under mild conditions.
see article for more examples
proposed mechanism
Key Words
primary amines, reductive amination, α-trifluoromethyl amines, organocatalysis
ID: J42-Y2023
